Description

5-Pyrimidinecarbonyl Chloride, 1,4-Dihydro-4-Oxo- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. Its value lies in its role as a versatile acylating agent, enabling the efficient introduction of the 1,4-dihydro-4-oxopyrimidine-5-carbonyl moiety into target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing nucleoside analogs, kinase inhibitors, and other heterocyclic active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators with pyrimidine-based structures.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules and ligands for metal-organic frameworks (MOFs) or catalysts.
• Bioconjugation & Probe Development: Utilized in medicinal chemistry to create labeled compounds or molecular probes for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 1,4-Dihydro-4-Oxo- (9Ci)
CAS No.	59793-47-4
Molecular Formula	C5H3ClN2O2
Molecular Weight	158.54 g/mol
Synonyms	4-Oxo-1,4-dihydropyrimidine-5-carbonyl chloride; 1,4-Dihydro-4-oxopyrimidine-5-carbonyl chloride; 5-Chlorocarbonyl-1,4-dihydro-4-oxopyrimidine; 4-Hydroxypyrimidine-5-carbonyl chloride; 5-(Chlorocarbonyl)-4-hydroxypyrimidine; 4-Oxo-3,4-dihydropyrimidine-5-carbonyl chloride; 1H-Pyrimidine-5-carbonyl chloride, 4-oxo-
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarbonyl Chloride is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable and can support regulatory filings with necessary documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.