Description

3-Hydroxyisonicotinoyl Chloride is a versatile and reactive acid chloride derivative of isonicotinic acid, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 3-hydroxyisonicotinoyl moiety into target molecules, enabling the construction of complex heterocyclic scaffolds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and organic electronic materials requiring specific pyridine-based architectures.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Hydroxyisonicotinoyl Chloride
CAS No.	59793-46-3
Molecular Formula	C6H4ClNO2
Molecular Weight	157.55 g/mol
Synonyms	3-Hydroxypyridine-4-carbonyl chloride; 4-Pyridinecarbonyl chloride, 3-hydroxy-; 3-Hydroxy-4-pyridinecarboxylic acid chloride; Isonicotinic acid, 3-hydroxy-, chloride; 3-Hydroxyisonicotinic acid chloride; 3-Hydroxypicolinoyl chloride (related isomer); 3-Hydroxy-4-carboxypyridine chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxyisonicotinoyl Chloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive acid chloride nature, the material must be kept under an inert atmosphere (e.g., nitrogen or argon) and protected from moisture to maintain stability and purity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Solubility	Soluble in common organic solvents (DMF, THF, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.