Description

1-Piperazinecarbonyl Chloride, 3-Oxo- (9Ci) is a versatile and highly reactive acyl chloride derivative used as a key building block in organic synthesis. Its primary value lies in its ability to efficiently introduce the piperazinecarbonyl moiety, a crucial structural feature in many active pharmaceutical ingredients. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex molecules and active intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing piperazine or piperazinone cores.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific heterocyclic amide structures are required.
• Organic Synthesis Reagent: Serves as a versatile reagent for introducing the 3-oxopiperazine-1-carbonyl group into target molecules via amidation or esterification reactions.
• Chemical Research & Development: Employed in academic and industrial R&D labs for constructing novel chemical libraries and exploring new synthetic pathways.
• Peptidomimetic Synthesis: Useful in the design and synthesis of peptidomimetics and other biologically active compounds that mimic peptide structures.

Basic Information

Product Name	1-Piperazinecarbonyl Chloride, 3-Oxo- (9Ci)
CAS No.	59702-68-0
Molecular Formula	C5H7ClN2O2
Molecular Weight	162.57 g/mol
Synonyms	3-Oxopiperazine-1-carbonyl chloride; 1-(Chlorocarbonyl)-3-oxopiperazine; 3-Oxo-1-piperazinecarbonyl chloride; 1-Piperazinecarbonyl chloride, 3-oxo-; 3-Oxopiperazinyl-1-carbonyl chloride; 1-Carbamoyl-3-oxopiperazine chloride; 3-Oxo-piperazine-1-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarbonyl Chloride, 3-Oxo- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards demanded by pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.