Description

2,5-Piperazinedione,3,6-Dihydroxy-1,4-Dimethyl-(9Ci) is a specialized heterocyclic diketopiperazine derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block and synthetic intermediate for the development of complex pharmacologically active molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce the diketopiperazine scaffold with defined stereochemistry into complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Development: Acts as a constrained dipeptide mimic for designing bioactive peptides with enhanced metabolic stability and receptor selectivity.
• Fine Chemical Synthesis: Intermediate for producing high-value specialty chemicals used in agrochemicals and advanced material science.

Basic Information

Product Name	2,5-Piperazinedione,3,6-Dihydroxy-1,4-Dimethyl-(9Ci)
CAS No.	59417-39-9
Molecular Formula	C6H10N2O4
Molecular Weight	174.16 g/mol
Synonyms	3,6-Dihydroxy-1,4-dimethylpiperazine-2,5-dione; 1,4-Dimethyl-3,6-dihydroxypiperazine-2,5-dione; Cyclo(Gly-HyPro); Cyclo(glycyl-hydroxyprolyl); Glycyl-hydroxyproline diketopiperazine; (3S,6S)-3,6-Dihydroxy-1,4-dimethylpiperazine-2,5-dione; (3R,6R)-3,6-Dihydroxy-1,4-dimethylpiperazine-2,5-dione
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3,6-Dihydroxy-1,4-Dimethyl-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer excess)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.