Description

2-Iodo-3-Methoxypyrazine is a halogenated pyrazine derivative, a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both an iodine substituent and a methoxy group on the pyrazine ring, makes it a critical intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by flavor and fragrance chemists exploring novel aroma compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyrazine core is a common bioactive motif.
• Flavor & Fragrance (F&F) Industry: Serves as a precursor for creating sophisticated pyrazine-based aroma chemicals, which contribute nutty, roasted, or earthy notes.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and other functional organic compounds.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form new carbon-carbon bonds.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Iodo-3-Methoxypyrazine
CAS No.	58139-04-1
Molecular Formula	C5H5IN2O
Molecular Weight	236.01 g/mol
Synonyms	3-Methoxy-2-iodopyrazine; 2-Iodo-3-methoxypyrazine; Pyrazine, 2-iodo-3-methoxy-; Iodomethoxypyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-3-Methoxypyrazine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR, or MS), and impurity profile is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and air. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.