Description

2-Iodo-6-Methoxypyrazine is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic reactivity of the iodine atom, enabling efficient cross-coupling reactions for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyrazine core for bioactivity.
• Material Science: Serves as a building block for creating specialized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for Suzuki, Stille, and Negishi couplings to introduce the methoxypyrazine moiety into more complex systems.
• Chemical Research & Development: Employed in academic and industrial R&D for methodological studies and exploring new synthetic pathways in heterocyclic chemistry.
• Ligand Preparation: Useful for synthesizing novel chelating ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	2-Iodo-6-Methoxypyrazine
CAS No.	58139-03-0
Molecular Formula	C5H5IN2O
Molecular Weight	236.01 g/mol
Synonyms	6-Methoxy-2-iodopyrazine; 2-Iodo-6-methoxypyrazine; Methoxyiodopyrazine; Iodomethoxypyrazine; Pyrazine, 2-iodo-6-methoxy-; 58139-03-0; 6-Methoxy-2-iodo-1,4-diazine
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-6-Methoxypyrazine is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, with specifications typically meeting or exceeding 98.0% (HPLC) purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and air. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.