Description

1,2-Isostearoylphosphatidylcholine is a synthetic phospholipid where the sn-1 and sn-2 positions of the glycerol backbone are esterified with isostearic acid. This specific molecular architecture is critical for its role as a high-performance lipid excipient and biomimetic membrane component. It is essential for formulators and researchers in the pharmaceutical and advanced cosmetic industries seeking enhanced stability and bioavailability. The compound is particularly valued for creating stable liposomes and lipid nanoparticles for targeted drug delivery and advanced dermal applications.

Application

• Pharmaceutical Excipient: A key component in the formulation of liposomes and lipid nanoparticles (LNPs) for the encapsulation and delivery of active pharmaceutical ingredients (APIs), including mRNA vaccines and chemotherapeutic agents.
• Biomimetic Membranes: Used in research to create model cell membranes for studying membrane-protein interactions, permeability, and biophysical properties due to its branched-chain fatty acid structure.
• Advanced Cosmetic Formulations: Employed as a premium emulsifier and skin-identical lipid in high-end skincare products to improve skin barrier function, enhance moisturization, and stabilize active ingredients.
• Nutraceutical Delivery Systems: Facilitates the development of lipid-based delivery systems for poorly water-soluble vitamins and nutraceuticals, improving their oral bioavailability.
• Diagnostic Reagents: Serves as a component in diagnostic kits and assays that require specific lipid environments for optimal reagent performance.
• Biomedical Research: A critical reagent in cell biology and biochemistry research for membrane fusion studies, lipid raft formation, and signal transduction experiments.

Basic Information

Product Name	1,2-Isostearoylphosphatidylcholine
CAS No.	58045-79-7
Molecular Formula	C44H86NO8P
Molecular Weight	788.13 g/mol
Synonyms	1,2-Diisostearoyl-sn-glycero-3-phosphocholine; Phosphatidylcholine, 1,2-diisostearoyl; DIiPC; Isostearoyl PC; 3-sn-Phosphatidylcholine, 1,2-diisostearoyl; L-α-Phosphatidylcholine, 1,2-diisostearoyl; Lipoid iPC; Synthetic Phospholipid iPC
EINECS	Contact for details

Quality Control

Our 1,2-Isostearoylphosphatidylcholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and cosmetic-grade lipids. Certificates of Analysis (COA) detailing purity, residual solvents, and other critical parameters are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines for excipient manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. For short-term use, the product may be stored at 2-8°C. The material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.