Description

Sodium [2R-(2Alpha,3Z,5Alpha)]-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate is a high-purity sodium salt derivative of a complex β-lactam structure, serving as a critical advanced pharmaceutical intermediate. Its precise stereochemistry and functional groups make it an essential building block for the synthesis of novel and potent β-lactam antibiotics. This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial agents and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel carbapenem and penem class antibiotics.
• Antibacterial Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antimicrobial agents.
• Fine Chemical Synthesis: Serves as a chiral building block for constructing complex heterocyclic molecules in organic synthesis.
• Process Development: Employed in scaling up and optimizing manufacturing routes for advanced β-lactam active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as an analytical standard for quality control and regulatory compliance in pharmaceutical production.

Basic Information

Product Name	Sodium [2R-(2Alpha,3Z,5Alpha)]-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
CAS No.	57943-81-4
Molecular Formula	C9H9NNaO5
Molecular Weight	234.16 g/mol
Synonyms	Sodium (2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate; (5R)-3-[(1Z)-2-Hydroxyethylidene]-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt; Sodium 3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate; β-lactam Intermediate Sodium Salt; Carbapenem Intermediate; Penem Derivative Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium [2R-(2Alpha,3Z,5Alpha)]-3-(2-Hydroxyethylidene)-7-Oxo-4-Oxa-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.