Description

1-Propyl Etodolac is a specific propyl derivative of the non-steroidal anti-inflammatory drug (NSAID) etodolac, identified by CAS NO 57816-83-8. This compound is of significant interest in pharmaceutical research and development, primarily as a key intermediate or reference standard for creating novel therapeutic agents. It is essential for organizations focused on drug discovery, process chemistry, and analytical method development. The material is particularly valuable for investigating structure-activity relationships and developing new anti-inflammatory or analgesic formulations.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel etodolac analogs and prodrugs.
• Research & Development: Used as a reference standard in analytical method development (HPLC, LC-MS) for impurity profiling and quantification.
• Drug Discovery: Employed in pharmacological studies to explore the impact of alkyl chain modification on COX-2 selectivity and therapeutic efficacy.
• Process Chemistry: Acts as a starting material or intermediate in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying NSAID metabolism, pharmacokinetics, and medicinal chemistry.
• Quality Control: Functions as a high-purity impurity standard to ensure the quality and consistency of etodolac API batches.

Basic Information

Product Name	1-Propyl Etodolac
CAS No.	57816-83-8
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	1-Propyl-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid; Propyl Etodolac; Etodolac Propyl Derivative; (±)-1-Propyl-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid; NSC 404585; 1-n-Propyl Etodolac
EINECS	Contact for details

Quality Control

Our 1-Propyl Etodolac CAS NO 57816-83-8 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.