Description

1-α-Hydroxyvitamin D3 is a biologically active metabolite and synthetic analog of Vitamin D3, also known as alfacalcidol. This compound is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) used to regulate calcium and phosphate metabolism. It is essential for manufacturers in the pharmaceutical and nutraceutical industries developing treatments for conditions related to vitamin D deficiency, such as osteoporosis, renal osteodystrophy, and hypoparathyroidism.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for treating metabolic bone diseases.
• Osteoporosis Treatment: Formulated into capsules, tablets, and oral solutions to increase bone mineral density.
• Renal Care Products: Key component in drugs for managing secondary hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease.
• Hypoparathyroidism Therapy: Used in hormone replacement therapies to maintain adequate serum calcium levels.
• Nutraceutical & Dietary Supplements: Incorporated into high-potency vitamin D supplements for targeted nutritional support.
• Veterinary Pharmaceuticals: Applied in formulations for treating calcium and bone disorders in animals.
• Research & Development: Serves as a reference standard and key intermediate in biochemical research and new drug development.

Basic Information

Item	Details
Product Name	1-α-Hydroxyvitamin D3
CAS No.	57651-82-8
Molecular Formula	C27H44O2
Molecular Weight	400.64 g/mol
Synonyms	Alfacalcidol; 1α-Hydroxycholecalciferol; 1α-OH-D3; 1α-Hydroxyvitamin D3; 1α-Hydroxycolecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β-diol; 1α,25-Dihydroxycholecalciferol precursor
EINECS	Contact for details

Quality Control

Our 1-α-Hydroxyvitamin D3 is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards (USP/EP). Every batch undergoes comprehensive analytical testing including HPLC for purity, identification by IR and UV spectroscopy, and specific tests for related substances and residual solvents. A Certificate of Analysis (COA) documenting all specifications is provided with each shipment to ensure traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in original packaging and opened only under controlled, low-humidity conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.