Description

3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole Monomaleate is a high-purity, specialized organic salt primarily used as a key pharmaceutical intermediate. This compound is valued for its role in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for research and development laboratories, custom synthesis providers, and pharmaceutical manufacturers requiring precise and reliable building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel drug candidates, especially β-adrenergic blocking agents (β-blockers).
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production chain for specific, high-value APIs requiring the 1,2,5-thiadiazole pharmacophore.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical & Clinical Trial Material Manufacturing: Supplied under controlled conditions for the production of materials used in non-clinical and clinical studies.
• Custom Synthesis & Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for the bespoke synthesis of client-targeted molecules.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing.

Basic Information

Product Name	3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole Monomaleate
CAS No.	57073-55-9
Molecular Formula	C17H28N4O5S
Molecular Weight	400.49 g/mol
Synonyms	Timolol Maleate Impurity; Timolol Maleate Related Compound; 3-[3-(tert-Butylamino)-2-hydroxypropoxy]-4-(morpholin-4-yl)-1,2,5-thiadiazole maleate; 4-Morpholino-3-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,5-thiadiazole maleate; Timolol Maleate EP Impurity; Timolol Impurity; (RS)-Timolol Maleate Intermediate; 1,2,5-Thiadiazole, 3-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-4-morpholinyl-, (Z)-2-butenedioate (1:1)
EINECS	Contact for details

Quality Control

Our 3-[3-(tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole Monomaleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and conformity to stringent specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.