Description

4-(Prop-2-Yn-1-Yl)Piperazin-1-Amine is a specialized piperazine derivative featuring a terminal alkyne functional group, making it a versatile and valuable building block in advanced organic synthesis. This compound is particularly significant for its role in click chemistry and medicinal chemistry research, where its reactive alkyne moiety enables efficient, modular construction of complex molecules. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical developers, and fine chemical manufacturers for creating novel molecular scaffolds and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Click Chemistry Reagent: The terminal alkyne group is essential for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and materials science.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the piperazine core for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating complex chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Incorporated into polymer backbones or as a functional handle on surfaces to modify material properties through post-polymerization modification.
• Biochemical Probe Synthesis: Utilized to create tagged molecules for studying biological processes, such as enzyme inhibitors or receptor ligands with reporter groups.

Basic Information

Item	Detail
Product Name	4-(Prop-2-Yn-1-Yl)Piperazin-1-Amine
CAS No.	56964-23-9
Molecular Formula	C7H13N3
Molecular Weight	139.20 g/mol
Synonyms	1-Amino-4-(2-propynyl)piperazine; 4-(2-Propynyl)-1-piperazinamine; N-(2-Propynyl)piperazin-1-amine; 1-Piperazinamine, 4-(2-propyn-1-yl)-; Propargylpiperazin-1-amine; 4-Propargylpiperazin-1-amine; 1-Propargylpiperazin-4-amine
EINECS	Contact for details

Quality Control

Our 4-(Prop-2-Yn-1-Yl)Piperazin-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.