Description

(1S)-1,2,3,4-Tetrahydro-8-Methoxy-1α,3β-Dimethyl-5-[(Ar)-4,5-Dimethoxy-2-Methyl-1-Naphthalenyl]Isoquinoline-6-Ol is a complex, chiral isoquinoline derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a sophisticated chemical intermediate or reference standard for developing novel bioactive molecules, particularly in alkaloid chemistry. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential therapeutic agents, especially those targeting neurological or cardiovascular pathways.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing and regulatory submissions.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the discovery of new alkaloid-based drug candidates.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex organic molecules.
• Biochemical Research: Potential use as a ligand or probe in studying enzyme interactions and receptor binding assays.
• Academic Studies: Used in advanced organic chemistry courses and research projects focusing on stereochemistry and multi-step synthesis.

Basic Information

Product Name	(1S)-1,2,3,4-Tetrahydro-8-Methoxy-1α,3β-Dimethyl-5-[(Ar)-4,5-Dimethoxy-2-Methyl-1-Naphthalenyl]Isoquinoline-6-Ol
CAS No.	56688-90-5
Molecular Formula	C₂₆H₃₁NO₅
Molecular Weight	437.53 g/mol
Synonyms	8-Methoxy-1α,3β-dimethyl-5-(4,5-dimethoxy-2-methyl-1-naphthyl)-1,2,3,4-tetrahydroisoquinolin-6-ol; (1S)-5-[(1R)-4,5-Dimethoxy-2-methyl-1-naphthalenyl]-8-methoxy-1,2,3,4-tetrahydro-1,3-dimethyl-6-isoquinolinol; NSC 339586; Aporphine alkaloid derivative; 1,2,3,4-Tetrahydro-8-methoxy-1,3-dimethyl-5-(4,5-dimethoxy-2-methyl-1-naphthyl)-6-isoquinolinol (S-configuration).
EINECS	Contact for details

Quality Control

Our (1S)-1,2,3,4-Tetrahydro-8-Methoxy-1α,3β-Dimethyl-5-[(Ar)-4,5-Dimethoxy-2-Methyl-1-Naphthalenyl]Isoquinoline-6-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.