Description

2-Bromopyrazine is a versatile halogenated heterocyclic building block essential for advanced organic synthesis. Its core value lies in its reactive bromine atom, which enables efficient cross-coupling reactions and functional group transformations to construct complex molecular architectures. This high-purity intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with pyrazine cores.
• Material Science Research: Used in the development of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Essential substrate for Suzuki, Stille, and Negishi couplings to form biaryl and other C-C bonds.
• Nucleophilic Substitution: Serves as an electrophile for reactions with various nucleophiles to introduce diverse functional groups onto the pyrazine ring.
• Ligand Preparation: Starting material for synthesizing specialized chelating ligands used in coordination chemistry and homogeneous catalysis.

Basic Information

Item	Detail
Product Name	2-Bromopyrazine
CAS No.	56423-63-3
Molecular Formula	C4H3BrN2
Molecular Weight	158.98 g/mol
Synonyms	Pyrazine, 2-bromo-; 2-Bromo-1,4-diazine; 2-Bromopyrazine; Bromopyrazine; NSC 404079; 1,4-Diazine, 2-bromo-; 2-Br-Pyz
EINECS	Contact for details

Quality Control

Our 2-Bromopyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or an amber container until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.