Description

1,2-Dipetroselenoyl-Sn-Glycero-3-Phosphocholine is a synthetic, high-purity phospholipid derivative, specifically a phosphatidylcholine analog where the sn-1 and sn-2 positions are esterified with petroselenoyl fatty acid chains. This compound is a critical research-grade biochemical for advanced studies in membrane biophysics and lipidomics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and specialty chemical manufacturers focused on developing novel liposomal drug delivery systems and investigating the role of specific phospholipids in cellular membrane function and signaling.

Application

• Liposome & Nanoparticle Formulation: A key component in the creation of specialized liposomes for targeted drug delivery, particularly for hydrophobic or sensitive active pharmaceutical ingredients (APIs).
• Membrane Biophysics Research: Used as a model membrane lipid to study bilayer fluidity, phase transition behavior, and the incorporation of selenated compounds into lipid structures.
• Biochemical Reagent: Serves as a substrate or standard in enzymatic assays involving phospholipases or for calibrating analytical instruments like mass spectrometers in lipidomic profiling.
• Pharmaceutical R&D: Employed in preclinical research for developing advanced parenteral formulations and investigating the impact of specific phospholipid structures on drug bioavailability and pharmacokinetics.
• Specialty Chemical Synthesis: Acts as a sophisticated building block or intermediate for the synthesis of more complex, functionalized phospholipids or labeled analogs for diagnostic applications.

Basic Information

Product Name	1,2-Dipetroselenoyl-Sn-Glycero-3-Phosphocholine
CAS No.	56391-91-4
Molecular Formula	C50H96NO10PSe2
Molecular Weight	1084.21 g/mol (approx.)
Synonyms	1,2-Di-(cis-6-octadecenoic acid)-sn-glycero-3-phosphocholine (selenium analog); Phosphatidylcholine, 1,2-di-petroselenoyl-; PC(18:1(6Z)/18:1(6Z)-Se); Selenated Phosphatidylcholine; Petroselenoyl PC; 1,2-Di-(6Z-octadecenoic acid)-3-phosphatidylcholine (selenium derivative); sn-Glycero-3-phosphocholine, 1,2-dipetroselenoyl ester
EINECS	Contact for details

Quality Control

Our 1,2-Dipetroselenoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation and NMR for structural verification, to ensure it meets the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to ensure long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Phosphorus Content)	≥ 98% of theoretical
Solubility	Soluble in chloroform, ethanol; forms liposomes in aqueous buffer
Heavy Metals	< 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.