Description

2-Oxohexanedioic Acid Tris(Trimethylsilyl) Deriv. is a high-purity, silylated derivative of α-ketoglutaric acid, designed for advanced synthetic and analytical applications. This compound is critical for protecting sensitive functional groups and enhancing volatility for gas chromatography analysis. It is primarily utilized by researchers and process chemists in pharmaceutical development, agrochemical synthesis, and analytical laboratories for precise chemical modification and detection.

Application

• Pharmaceutical Intermediate: Used as a key protected synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Gas Chromatography (GC) Analysis: Serves as a derivatization agent to improve the volatility and thermal stability of carboxylic acids and ketones for accurate GC and GC-MS analysis.
• Organic Synthesis Reagent: Protects carboxyl and carbonyl groups during multi-step synthesis, particularly in peptide and natural product chemistry.
• Biochemical Research: Employed in metabolic studies and enzyme research related to the Krebs cycle (citric acid cycle) as a derivative of α-ketoglutarate.
• Agrochemical Development: Acts as a building block in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Used in the development of specialty silicon-containing polymers and advanced materials.

Basic Information

Product Name	2-Oxohexanedioic Acid Tris(Trimethylsilyl) Deriv.
CAS No.	56272-88-9
Molecular Formula	C15H32O5Si3
Molecular Weight	376.67 g/mol
Synonyms	α-Ketoglutaric Acid Tris(trimethylsilyl) Ester; 2-Oxopentanedioic Acid Tris-O-(trimethylsilyl) Derivative; Tris(trimethylsilyl) 2-Oxoglutarate; 2-Oxoglutaric Acid Tris(TMS) Ester; TMS Derivative of α-Ketoglutaric Acid; Hexanedioic Acid, 2-oxo-, 1,2,6-tris(trimethylsilyl) ester; 1,2,6-Tris-O-(trimethylsilyl)-α-ketoglutaric Acid
EINECS	Contact for details

Quality Control

Our 2-Oxohexanedioic Acid Tris(Trimethylsilyl) Deriv. is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.