Description

Pterosins CAS NO 56227-00-0 are a class of natural sesquiterpenoid compounds, primarily recognized for their role as potent and selective inhibitors of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This targeted biological activity makes them valuable research tools for investigating metabolic pathways and related disorders. These compounds are essential for pharmaceutical R&D, particularly in the fields of endocrinology, metabolic disease research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Critical as reference standards and bioactive probes in studies targeting 11β-HSD1 for conditions like metabolic syndrome, type 2 diabetes, and obesity.
• Biochemical Assay Development: Used as specific enzyme inhibitors to validate high-throughput screening (HTS) assays and study corticosteroid metabolism.
• Academic & Institutional Research: Serves as a key chemical tool in university and government labs for fundamental research in steroid biology and enzymology.
• Preclinical Studies: Employed in animal models to elucidate the physiological role of 11β-HSD1 and evaluate potential therapeutic efficacy of inhibition.
• Chemical Synthesis Intermediate: Acts as a sophisticated starting material or intermediate for the semi-synthesis of novel analogs with optimized pharmacological profiles.
• Diagnostic Kit Development: Potential use in the formulation of diagnostic reagents for research purposes related to glucocorticoid activity.

Basic Information

Product Name	Pterosins
CAS No.	56227-00-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pterosin; Pterosin B; (3aS,4R,7S,7aS)-4,7-Dimethyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoinden-1-one; 11β-HSD1 Inhibitor; 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor; NSC 113495; Sesquiterpenoid Pterosin
EINECS	Contact for details

Quality Control

Our Pterosins are produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Standard Research Grade)
Purity (HPLC)	≥98% (High Purity Grade)
Water Content (KF)	<1.0%
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.