Description

[α-(Acetylamino)-4-(Acetyloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring both phosphonic acid and silyl ester protecting groups. This chemical is a critical synthetic intermediate, valued for its role in constructing complex molecules where precise control over phosphonate functionality is required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting bone-related disorders or requiring phosphonate-based bioisosteres.
• Agrochemical Research: Used in the development of next-generation herbicides, plant growth regulators, and pesticides that leverage phosphonate chemistry.
• Peptide Mimetics & Prodrug Synthesis: Serves as a protected phosphonate precursor for creating peptide analogs and prodrugs designed for improved bioavailability and targeted delivery.
• Material Science Precursor: Potential monomer or modifying agent in the development of specialty polymers, coatings, or flame retardants with specific functional properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and enzyme inhibitors for biochemical pathway studies.
• Process Chemistry: Used in scalable route development for active pharmaceutical ingredients (APIs) where the bis(trimethylsilyl) ester group offers advantageous solubility and handling properties.

Basic Information

Item	Detail
Product Name	[α-(Acetylamino)-4-(Acetyloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56196-76-0
Molecular Formula	C19H32NO6PSi2
Molecular Weight	457.60 g/mol
Synonyms	N-[2-[4-(Acetyloxy)phenyl]-1-[(bis(trimethylsilyloxy)phosphinyl]ethyl]acetamide; α-Acetamido-4-acetoxyphenethylphosphonic Acid Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) [α-(acetylamino)-4-(acetyloxy)phenethyl]phosphonate; Phosphonic Acid, [α-(acetylamino)-4-(acetyloxy)phenethyl]-, Bis(trimethylsilyl) Ester; 56196-76-0; Protected Phosphonate Ester Intermediate
EINECS	Contact for details

Quality Control

Every batch of [α-(Acetylamino)-4-(Acetyloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and development, as well as cGMP standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent hydrolysis of the silyl ester groups. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.