Description

o-Methoxymandelic Acid (Tms) is a specialized organic compound featuring both a methoxy and a trimethylsilyl (Tms) protecting group on a mandelic acid core. This functionalized derivative is a crucial building block and protected intermediate in advanced organic synthesis, particularly for pharmaceuticals and fine chemicals. It is primarily utilized by research institutions, pharmaceutical R&D labs, and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs) and complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Used as a protected chiral synthon for constructing molecules with specific stereochemistry in medicinal chemistry.
• Fine Chemical Production: Serves as a precursor in the manufacture of specialty chemicals, agrochemicals, and advanced materials.
• Research & Development: Essential compound in academic and industrial R&D labs for method development and exploring new synthetic pathways.
• Peptide and Natural Product Synthesis: Utilized in the synthesis of peptide analogs and complex natural product derivatives where protecting group chemistry is required.

Basic Information

Product Name	o-Methoxymandelic Acid (Tms)
CAS No.	55530-66-0
Molecular Formula	C12H18O4Si
Molecular Weight	254.35 g/mol
Synonyms	2-Methoxymandelic Acid Trimethylsilyl Ester; (2-Methoxyphenyl)(trimethylsilyloxy)acetic Acid; α-(Trimethylsiloxy)-o-methoxyphenylacetic Acid; TMS Ether of o-Methoxymandelic Acid; Trimethylsilyl 2-Methoxymandelate; o-(Trimethylsiloxy)methoxyphenylacetic Acid
EINECS	Contact for details

Quality Control

Our o-Methoxymandelic Acid (Tms) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.