Description

N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester is a highly derivatized, silylated form of the essential amino acid L-Lysine, designed for advanced synthetic and analytical applications. This compound is critical for protecting reactive amine and carboxylic acid functional groups, enabling complex multi-step organic syntheses where standard amino acid reactivity is undesirable. It is primarily utilized by researchers and process chemists in pharmaceutical development, peptide synthesis, and analytical chemistry as a key building block or derivatization agent.

Application

• Advanced Peptide Synthesis: Serves as a protected lysine derivative for solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Pharmaceutical Intermediate: Acts as a crucial building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Gas Chromatography (GC) and Mass Spectrometry (MS): Used as a derivatization agent to increase the volatility and thermal stability of amino acids for precise analytical detection.
• Protecting Group Chemistry: Provides robust trimethylsilyl (TMS) protection for both the α-amino and side-chain amine groups, facilitating selective deprotection strategies.
• Bioconjugation and Probe Development: Enables the controlled modification of biomolecules for research in chemical biology and diagnostics.
• Material Science Research: Employed in the synthesis of specialized amino acid-based polymers and functional materials.

Basic Information

Product Name	N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester
CAS No.	55429-07-7
Molecular Formula	C18H45N2O2Si4
Molecular Weight	441.92 g/mol
Synonyms	L-Lysine, N2,N6,N6-tris(trimethylsilyl)-, trimethylsilyl ester; N2,N6,N6-Tris-O-(trimethylsilyl)-L-lysine trimethylsilyl ester; TMS-L-Lysine-TMS ester; Fully silylated L-Lysine; Nα,Nε,Nε-Tris(trimethylsilyl)-L-lysine trimethylsilyl ester; (S)-2,6-Bis(trimethylsilylamino)hexanoic acid trimethylsilyl ester; Per-TMS-L-Lysine
EINECS	Contact for details

Quality Control

Our N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester is manufactured under controlled conditions to ensure high chemical purity and consistency. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to confirm identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.