Description

2-Bromophenylacetyl Chloride is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 2-bromophenylacetyl moiety, a key structural feature for developing compounds with specific biological and material properties. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders.
• Agrochemical Synthesis: Used in the manufacture of herbicides and pesticides, where the bromine atom and acyl chloride functionality enable specific modes of action.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics and Conjugation: Facilitates the acylation of amines in peptides and biomolecules to create novel conjugates for drug discovery.
• Polymer and Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and advanced organic materials.
• Custom Synthesis and R&D: A fundamental reagent for medicinal chemistry and process research in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	2-Bromophenylacetyl Chloride
CAS No.	55116-09-1
Molecular Formula	C8H6BrClO
Molecular Weight	233.49 g/mol
Synonyms	2-Bromobenzeneacetyl chloride; (2-Bromophenyl)acetyl chloride; α-Bromo-o-toluoyl chloride; o-Bromophenylacetyl chloride; 2-Bromo-α-toluoyl chloride; (2-Bromophenyl)acetic acid chloride; NSC 403119
EINECS	Contact for details

Quality Control

Our 2-Bromophenylacetyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and titration methods, to confirm identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, amines, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Isolate from incompatible materials such as oxidizers and alkalis.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.