Description

1-Methyl-4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester is a key protected intermediate in advanced organic synthesis, valued for its role in constructing complex nitrogen-containing heterocycles. Its primary importance lies in facilitating the synthesis of pharmacologically active compounds by providing a stable, silyl-protected carboxylic acid functionality. This product is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those working on central nervous system (CNS) agents, analgesics, and novel piperidine-based scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potent opioid analgesics and other CNS-active pharmaceuticals.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates targeting pain receptors and neurological pathways.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating complex piperidine derivatives and other specialty organic compounds.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for studying reaction mechanisms and developing new synthetic methodologies in organic chemistry.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control in API manufacturing.

Basic Information

Product Name	1-Methyl-4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester
CAS No.	54833-74-8
Molecular Formula	C16H25NO2Si
Molecular Weight	291.47 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, trimethylsilyl ester; 1-Methyl-4-phenyl-4-(trimethylsilyloxycarbonyl)piperidine; Trimethylsilyl 1-methyl-4-phenyl-4-piperidinecarboxylate; 4-Carboxy-1-methyl-4-phenylpiperidine trimethylsilyl ester; Pethidine intermediate silyl ester; Meperidine acid TMS ester; TMS ester of 1-methyl-4-phenyl-4-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-Phenyl-4-Piperidinecarboxylic Acid Trimethylsilyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.