Description

(5Z,22E)-9,10-Secoergosta-5,10(19),22-Triene-3β,7,8ξ-Triol CAS NO 54661-20-0 is a high-purity, synthetic secosterol derivative, a key intermediate in the synthesis of vitamin D analogs and other biologically active steroidal compounds. Its precise stereochemistry and high purity are critical for ensuring the efficacy and safety of downstream pharmaceutical and research applications. This compound is essential for manufacturers and research institutions in the pharmaceutical, nutraceutical, and life science sectors developing advanced therapeutic and nutritional products.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active vitamin D metabolites (e.g., calcitriol, tacalcitol) and other therapeutic secosteroids.
• Biochemical Research: Used as a reference standard and building block in studies of vitamin D receptor (VDR) signaling pathways and steroid hormone metabolism.
• Nutraceutical Development: Serves as a key intermediate for the production of high-value vitamin D supplements and fortified food ingredients.
• Chemical Synthesis: A versatile chiral synthon for constructing complex steroidal frameworks in organic and medicinal chemistry.
• Analytical Standard: Employed as a certified reference material (CRM) for quality control and assay validation in pharmaceutical and food testing laboratories.

Basic Information

Product Name	(5Z,22E)-9,10-Secoergosta-5,10(19),22-Triene-3β,7,8ξ-Triol
CAS No.	54661-20-0
Molecular Formula	C₂₇H₄₂O₃
Molecular Weight	414.62 g/mol
Synonyms	9,10-Secoergosta-5,10(19),22-trien-3β,7ξ,8ξ-triol; (5Z,7E,22E)-9,10-Seco-5,7,10(19),22-ergostatetraene-3β,7,8-triol; Vitamin D3 Triol; 1α,25-Dihydroxyvitamin D3 Triol Precursor; 3β,7ξ,8ξ-Trihydroxy-9,10-seco-5,10(19),22-cholatrien-24-oic Acid Methyl Ester Derivative; Secosterol Triol Intermediate
EINECS	Contact for details

Quality Control

Every batch of our (5Z,22E)-9,10-Secoergosta-5,10(19),22-Triene-3β,7,8ξ-Triol is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support its use in GMP-compliant pharmaceutical applications. Our standard quality commitment includes rigorous testing for identity, purity, and stereochemical integrity via advanced chromatographic and spectroscopic methods. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.