Description

Aminooxy-Peg2-Methane is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group. This compound is essential for creating stable oxime bonds with aldehydes and ketones, enabling precise bioconjugation and surface functionalization. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, where controlled and site-specific coupling is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of payloads (drugs, toxins, fluorophores) to antibodies or proteins via carbonyl groups.
• Surface Functionalization: Modification of sensor chips, nanoparticles, and diagnostic assay surfaces with biomolecules for enhanced specificity and performance.
• Polymer Chemistry and Material Science: Serving as a building block for synthesizing functionalized PEG-based hydrogels, coatings, and smart materials.
• Peptide and Protein Modification: Introduction of PEG chains (PEGylation) to improve pharmacokinetic properties such as solubility and stability.
• Crosslinking Agent: Creating stable crosslinks between polymers or biomolecules in the development of novel biomaterials and drug delivery systems.
• Diagnostic Reagent Synthesis: Fabrication of labeled probes and reagents for immunoassays and other diagnostic platforms.

Basic Information

Product Name	Aminooxy-Peg2-Methane
CAS No.	54149-49-4
Molecular Formula	C9H19NO5
Molecular Weight	221.25 g/mol
Synonyms	2-[2-(2-Aminoethoxy)ethoxy]ethanamine O-methyloxime; Aminooxy-PEG2-methane; Aminooxy-PEG2-CH3; O-(2-Aminoethyl)-O'-(2-{[(methylamino)oxy]methyl}ethyl)ethylene glycol; Aminooxy-dPEG®2; Aminooxy-PEG2-methyl; Aminooxy-PEG2-alkane; Aminooxy-functionalized PEG linker
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg2-Methane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.