Description

n-Methyl Trimetazidine Dihydrochloride is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for research and development in cardiovascular pharmacology, serving as a key derivative of the established anti-ischemic agent trimetazidine. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories for drug development, metabolic studies, and quality control processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis and development of novel cardioprotective drugs and related analogs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical manufacturing.
• Biochemical Research: Employed in metabolic and pharmacological studies to investigate mechanisms of cellular protection under ischemic conditions.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor or derivative in the formulation of potential new chemical entities (NCEs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-Methyl Trimetazidine Dihydrochloride
CAS No.	53960-20-6
Molecular Formula	C15H24N2O3 · 2HCl
Molecular Weight	369.29 g/mol (as dihydrochloride)
Synonyms	1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride; N-Methyl Trimetazidine 2HCl; Trimetazidine Methyl Derivative Dihydrochloride; 53960-20-6; 1-(3,4,5-Trimethoxybenzyl)-4-methylpiperazine Dihydrochloride; TMZ Methyl Derivative Dihydrochloride
EINECS	Contact for details

Quality Control

Our n-Methyl Trimetazidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.