Description

1-[1-[3-(2-Acetylphenoxy)-2-Hydroxypropyl]-4-Piperidyl]-1,3-Dihydro-2H-Benzimidazol-2-One is a high-purity, complex organic compound serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its intricate molecular structure, featuring fused benzimidazole and piperidine rings, makes it an essential building block for developing novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents and other specialized therapeutic molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel benzimidazole-derived active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the development of potential therapeutic agents targeting central nervous system (CNS) disorders.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Biochemical Research: Employed as a reference standard or a ligand in biochemical assay development and pharmacological studies.

Basic Information

Product Name	1-[1-[3-(2-Acetylphenoxy)-2-Hydroxypropyl]-4-Piperidyl]-1,3-Dihydro-2H-Benzimidazol-2-One
CAS No.	53828-24-3
Molecular Formula	C23H27N3O4
Molecular Weight	409.48 g/mol
Synonyms	1-(1-{3-[(2-Acetylphenyl)oxy]-2-hydroxypropyl}-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 2-Oxo-1-[1-[3-(2-acetylphenoxy)-2-hydroxypropyl]-4-piperidyl]benzimidazoline; 1,3-Dihydro-1-[1-[3-(2-acetylphenoxy)-2-hydroxypropyl]-4-piperidinyl]-2H-benzimidazol-2-one; 53828-24-3; UNII-8B6H8F2Q8W; 8B6H8F2Q8W
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects requiring material suitable for use under GMP (Good Manufacturing Practice) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term stability is required. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.