Description

(1As)-1,1Aα,2,3,4,4Aβ,5,7Bα-Octahydro-1,1,4α,7-Tetramethyl-6H-Cyclopropa[E]Azulene-6-One CAS NO 53584-68-2 is a high-purity, complex sesquiterpene ketone derivative valued for its unique structural framework. This compound is a critical advanced intermediate and a versatile building block in sophisticated organic synthesis. It is primarily sought by pharmaceutical research and fine chemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly in steroid and terpenoid-based therapeutic research.
• Fragrance & Flavor Chemistry: Used as a high-value intermediate for creating novel synthetic ambergris or woody-amber odorants and complex flavor molecules.
• Organic Synthesis Building Block: Its intricate polycyclic structure makes it valuable for constructing complex natural product analogs and molecular scaffolds in academic and industrial R&D.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials with specific optical or structural properties.
• Catalysis & Ligand Development: Potential use in the development of novel chiral ligands or organocatalysts due to its rigid, three-dimensional structure.

Basic Information

Product Name	(1As)-1,1Aα,2,3,4,4Aβ,5,7Bα-Octahydro-1,1,4α,7-Tetramethyl-6H-Cyclopropa[E]Azulene-6-One
CAS No.	53584-68-2
Molecular Formula	C₁₅H₂₂O
Molecular Weight	218.33 g/mol
Synonyms	6H-Cyclopropa[e]azulen-6-one, 1,1a,2,3,4,4a,5,7b-octahydro-1,1,4a,7-tetramethyl-, [1aR-(1aα,4aβ,7bα)]-; Ambrox; Ambroxan; Ambroxide; 1,1a,2,3,4,4a,5,7b-Octahydro-1,1,4a,7-tetramethyl-6H-cyclopropa[e]azulen-6-one; (1aR,4aS,7aS,7bS)-1,1,4a,7-Tetramethyl-1a,2,3,4,4a,5,6,7b-octahydro-1H-cyclopropa[e]azulen-7a-ol (related alcohol); Synthetic Ambergris; (-)-Ambrox
EINECS	Contact for details

Quality Control

Our production of (1As)-1,1Aα,2,3,4,4Aβ,5,7Bα-Octahydro-1,1,4α,7-Tetramethyl-6H-Cyclopropa[E]Azulene-6-One adheres to stringent internal quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC/GC for purity and chiral analysis to ensure structural and isomeric integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC/GC)	≥ 98.0%
Optical Rotation [α]²⁰D	Specified range provided on COA
Melting Point	Specified range provided on COA
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.