Description

Sodium (41S,12R,13As)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5] Naphthyridine-12-Carboxylate is a high-purity, complex organic sodium salt with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate or reference standard. Its value lies in enabling the synthesis and quality control of sophisticated active pharmaceutical ingredients (APIs), particularly in alkaloid and heterocyclic chemistry. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, especially those with indole and naphthyridine core structures.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical R&D and manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and as a precursor for creating novel chemical entities for biological screening.
• Process Chemistry: Serves as a standardized intermediate for scaling up API production under current Good Manufacturing Practices (cGMP).
• Academic Research: Utilized in universities and research institutes for studies in organic synthesis, natural product chemistry, and pharmacology.

Basic Information

Product Name	Sodium (41S,12R,13As)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5] Naphthyridine-12-Carboxylate
CAS No.	53448-45-6
Molecular Formula	C22H25N3O3•Na
Molecular Weight	402.45 g/mol
Synonyms	Sodium 13a-Ethyl-12-hydroxy-2,3,4a,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; (41S,12R,13As)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5] Naphthyridine-12-Carboxylic Acid Sodium Salt; AJIC-A2 Sodium Salt; AJIC-A2 (sodium); AJIC-A2-Na; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested to meet stringent quality standards suitable for pharmaceutical R&D. Our rigorous quality control includes identity confirmation, purity assessment, and impurity profiling using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), related substances, and residual solvents is provided with each shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 5.0% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.