Description

Menadiol Dibutyrate is a synthetic, fat-soluble form of vitamin K, specifically a diester derivative of menadiol. This compound serves as a stable and bioavailable precursor, playing a critical role in the synthesis of prothrombin and other blood clotting factors in the liver. It is essential for manufacturers in the pharmaceutical and nutraceutical industries requiring a reliable source of vitamin K activity for formulations targeting coagulation disorders and nutritional supplementation. Menadiol Dibutyrate CAS NO 53370-44-8 offers enhanced stability compared to some other vitamin K forms.

Application

• Pharmaceutical Active Ingredient: Used in the formulation of injectable and oral medications for the treatment and prevention of hypoprothrombinemia and vitamin K deficiency bleeding (VKDB).
• Nutraceutical & Dietary Supplements: Incorporated into vitamin K supplements, multivitamin complexes, and specialized health products aimed at supporting bone and cardiovascular health.
• Veterinary Medicine: Employed in feed additives and therapeutic preparations to prevent hemorrhagic conditions in livestock and poultry.
• Research & Development: Serves as a key reference standard and biochemical reagent in life science research, particularly in studies of coagulation pathways and vitamin K metabolism.
• Cosmeceutical Applications: Explored in topical formulations for its potential benefits in skin health, including reducing the appearance of dark circles and bruising.

Basic Information

Product Name	Menadiol Dibutyrate
CAS No.	53370-44-8
Molecular Formula	C23H32O4
Molecular Weight	372.50 g/mol
Synonyms	Vitamin K4 Dibutyrate; Menadiol Di-n-butyrate; 2-Methyl-1,4-naphthalenediol Dibutyrate; 2-Methyl-1,4-naphthohydroquinone Dibutyrate; 1,4-Dihydroxy-2-methylnaphthalene Dibutyrate; Menadiol Dibehenate (common misnomer, correct is dibutyrate); K4 Vitamin
EINECS	258-548-1

Quality Control

Our Menadiol Dibutyrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and nutraceutical applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Compliance with relevant pharmacopeial monographs (such as USP/NF) can be supported upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); therefore, containers should be kept tightly sealed under an inert gas (e.g., nitrogen or argon) after opening to maintain stability and potency. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0%
Melting Point	48°C - 52°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.