Description

N-Methyl-n-Trimethylsilylheptafluorobutyramide is a specialized organosilicon reagent featuring a perfluorinated acyl group and a trimethylsilyl-protected amine. This compound is valued for its role as a powerful derivatization agent, enhancing the volatility and detectability of analytes in sensitive analytical techniques. It is primarily sought by analytical laboratories and R&D departments in the pharmaceutical, environmental, and agrochemical industries for gas chromatography (GC) and mass spectrometry (MS) applications.

Application

• Derivatization Reagent for GC/MS Analysis: Used to silylate polar functional groups (e.g., -OH, -COOH, -NH) in complex mixtures for improved chromatographic separation and detection.
• Pharmaceutical Impurity Profiling: Employed in the analysis of drug metabolites, degradation products, and trace impurities to meet regulatory standards.
• Environmental Monitoring: Facilitates the detection and quantification of trace-level pollutants, pesticides, and endocrine disruptors in water and soil samples.
• Metabolomics and Biomarker Discovery: A key reagent for preparing biological samples (urine, plasma, tissue extracts) to identify metabolic signatures in disease research.
• Forensic Toxicology: Used in the derivatization of drugs of abuse and their metabolites for confirmatory analysis.
• Polymer and Material Science: Acts as a silylating agent in surface modification and the synthesis of fluorinated silicon-based materials.

Basic Information

Product Name	N-Methyl-n-Trimethylsilylheptafluorobutyramide
CAS No.	53296-64-3
Molecular Formula	C9H12F7NOSi
Molecular Weight	311.28 g/mol
Synonyms	MSTFA-HFB; N-Methyl-N-(trimethylsilyl)heptafluorobutyramide; Heptafluorobutyric acid N-methyl-N-(trimethylsilyl)amide; N-Methyl-N-trimethylsilylheptafluorobutyramide; Derivatization reagent MSTFA/HFB; 3,3,4,4,5,5,5-Heptafluoro-N-methyl-N-(trimethylsilyl)pentanamide; Silylation reagent for GC; HFB-Amide derivatizing agent
EINECS	Contact for details

Quality Control

Our N-Methyl-n-Trimethylsilylheptafluorobutyramide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for analytical applications. Each lot is tested using advanced techniques including GC, NMR, and Karl Fischer titration. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.