Description

(1S,9S,11S,12E,14E,19Z,22R)-9,11-Dihydroxy-22-Methyl-6,23-Dioxa-26-Thia-2,17,27-Triazatricyclo[17.5.2.14,7]Heptacosa-4,7(27),12,14,19-Pentene-3,8,24-Trione is a complex, high-purity macrolide-derived compound with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical research and development. Its intricate polycyclic structure makes it a valuable scaffold for synthesizing novel bioactive molecules targeting specific enzymatic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing new therapeutic agents, particularly in oncology and anti-infective fields.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel macrolide-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Serves as a probe or inhibitor in enzymatic assays to study specific biological pathways and mechanisms of action.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex natural product derivatives.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Item	Details
Product Name	(1S,9S,11S,12E,14E,19Z,22R)-9,11-Dihydroxy-22-Methyl-6,23-Dioxa-26-Thia-2,17,27-Triazatricyclo[17.5.2.14,7]Heptacosa-4,7(27),12,14,19-Pentene-3,8,24-Trione
CAS No.	53216-90-3
Molecular Formula	C₂₄H₃₀N₃O₇S
Molecular Weight	504.58 g/mol
Synonyms	9,11-Dihydroxy-22-methyl-6,23-dioxa-26-thia-2,17,27-triazatricyclo[17.5.2.14,7]heptacosa-4,7(27),12,14,19-pentaene-3,8,24-trione; (1S,9S,11S,12E,14E,19Z,22R)-form; Macrolactam Sulfur Derivative; Tricyclic Macrolide Intermediate; 53216-90-3; CAS 53216-90-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.