Description

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) belonging to the indole acetic acid class, functioning as a prodrug of indomethacin. It is valued for its targeted therapeutic action and improved gastrointestinal tolerability profile compared to its active metabolite. This compound is primarily required by pharmaceutical manufacturers and research institutions for the development and production of analgesic and anti-inflammatory medications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of oral solid dosage forms such as tablets and capsules for the treatment of pain and inflammation.
• Analgesic Drug Development: Used in R&D for creating new analgesic medications targeting conditions like osteoarthritis, rheumatoid arthritis, and postoperative pain.
• Anti-inflammatory Formulations: Serves as a key intermediate or direct API in anti-inflammatory creams, gels, or other topical preparations.
• Biochemical Research: Employed as a reference standard or inhibitor in pharmacological studies investigating cyclooxygenase (COX) pathways and inflammation mechanisms.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing pain and inflammation in animals.
• Generic Drug Manufacturing: Essential for companies producing generic versions of acemetacin-based medications, ensuring bioequivalence and therapeutic efficacy.

Basic Information

Product Name	Acemetacin
CAS No.	53164-05-9
Molecular Formula	C21H18ClNO6
Molecular Weight	415.82 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester; TVX 1322; Acemetacine; Acemetacino; Acemetacinum; Rantudil; Emflex; [1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic acid
EINECS	Contact for details

Quality Control

Our Acemetacin is manufactured and tested under strict quality management systems. We ensure compliance with current Good Manufacturing Practice (cGMP) guidelines and relevant pharmacopoeial standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.