Description

2,3-Difluoro-Pyrazine is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its ability to introduce fluorine atoms and a pyrazine core into target molecules, significantly altering their electronic properties, metabolic stability, and bioavailability. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where fluorine substitution enhances activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis and coordination chemistry.
• Functional Material Precursor: Employed in the research and development of electronic materials, liquid crystals, and organic semiconductors.
• Fluorine Chemistry Research: A versatile reagent for studying nucleophilic aromatic substitution and other fluorination-related reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules under cGMP conditions.

Basic Information

Item	Detail
Product Name	2,3-Difluoro-Pyrazine
CAS No.	52751-15-2
Molecular Formula	C4H2F2N2
Molecular Weight	116.07 g/mol
Synonyms	2,3-Difluoropyrazine; Pyrazine, 2,3-difluoro-; 2,3-Difluoro-1,4-diazine; 2,3-Difluoropyrazine (52751-15-2); Difluoropyrazine; 2,3-Difluoro-pyrazine; 2,3-Difluor-1,4-diazin
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-Pyrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.