Description

(2S)-Ethyl 3,6-dioxopiperazine-2-acetate, also known as 2-Piperazineacetic Acid, 3,6-Dioxo-, Ethyl Ester, (2S)-, is a high-purity chiral piperazine derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of complex molecules, particularly in the pharmaceutical sector. It is primarily utilized by research institutions and chemical manufacturers focused on active pharmaceutical ingredient (API) development and fine chemical production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral agents, and other complex therapeutic molecules.
• Peptidomimetic Research: Used to construct constrained peptide analogs and scaffolds for drug discovery programs targeting various diseases.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Chemical Biology Probes: Useful for creating labeled or modified compounds to study biological pathways and enzyme functions.
• Fine Chemical Production: Serves as a precursor for specialty chemicals requiring high enantiomeric purity and specific functional groups.

Basic Information

Product Name	(2S)-Ethyl 3,6-dioxopiperazine-2-acetate
CAS No.	52661-95-7
Molecular Formula	C8H12N2O4
Molecular Weight	200.19 g/mol
Synonyms	2-Piperazineacetic Acid, 3,6-Dioxo-, Ethyl Ester, (2S)-; (S)-Ethyl 3,6-dioxopiperazine-2-acetate; Ethyl (S)-3,6-dioxopiperazine-2-acetate; L-3,6-Dioxo-2-piperazineacetic Acid Ethyl Ester; (2S)-3,6-Dioxo-2-piperazineacetic Acid Ethyl Ester; (S)-3,6-Dioxopiperazine-2-acetic Acid Ethyl Ester; Ethyl (S)-2-(3,6-dioxopiperazin-2-yl)acetate
EINECS	Contact for details

Quality Control

Our (2S)-Ethyl 3,6-dioxopiperazine-2-acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.