Description

n-(Trifluoroacetyl)-L-Methionine Trimethylsilyl Ester is a high-purity, protected amino acid derivative primarily used as a critical synthetic intermediate. Its value lies in enabling precise chemical modifications of the methionine side chain, essential for advanced peptide synthesis and pharmaceutical research. This compound is particularly needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for developing novel active compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate protected methionine residues, preventing unwanted side reactions.
• Proteomics Research: Serves as a reagent in chemical proteomics for labeling and studying protein function and interactions.
• Metabolite Analysis: Employed in the derivatization of amino acids for enhanced detection and separation in analytical techniques like GC-MS and LC-MS.
• Agrochemical Development: Intermediate in the research and production of specialized amino acid-derived crop protection agents.
• Bioconjugation Chemistry: Facilitates the site-specific modification of proteins and other biomolecules for therapeutic and diagnostic applications.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Methionine Trimethylsilyl Ester
CAS No.	52558-92-6
Molecular Formula	C11H20F3NO3SSi
Molecular Weight	331.43 g/mol
Synonyms	L-Methionine, N-[(trifluoroacetyl)-, trimethylsilyl ester; N-(Trifluoroacetyl)-L-methionine TMS ester; N-TFA-L-Methionine trimethylsilyl ester; Trimethylsilyl N-(trifluoroacetyl)-L-methioninate; (2S)-2-[(Trifluoroacetyl)amino]-4-(methylsulfanyl)butanoic acid trimethylsilyl ester; TFA-L-Met-OTMS; N-[(Trifluoroacetyl)-L-methionine O-trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Methionine Trimethylsilyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.