Description

L-Valine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester CAS NO 52558-81-3 is a high-purity, protected amino acid derivative designed for advanced synthetic applications. This compound is a critical reagent in peptide synthesis and pharmaceutical research, offering enhanced reactivity and stability for complex molecular construction. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers requiring precise and reliable building blocks for bioactive molecules.

Application

• Peptide Synthesis Intermediate: Serves as a key protected valine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research & Development: Used in the synthesis of novel drug candidates, peptidomimetics, and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: Acts as a precursor for introducing valine residues into biomolecules for labeling or structural modification studies.
• Organic Synthesis Building Block: Employed in the preparation of complex organic molecules where a protected amino acid functionality is required.
• Proteomics & Biochemical Research: Utilized in metabolic studies and the synthesis of isotopically labeled amino acids for tracer applications.
• Fine Chemical Production: An essential intermediate in the multi-step synthesis of specialty chemicals and advanced materials.

Basic Information

Item	Detail
Product Name	L-Valine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester
CAS No.	52558-81-3
Molecular Formula	C12H22F3NO3Si
Molecular Weight	313.39 g/mol
Synonyms	N-(Trifluoroacetyl)-L-valine trimethylsilyl ester; L-Valine, N-trifluoroacetyl-, trimethylsilyl ester; Trimethylsilyl N-trifluoroacetyl-L-valinate; N-TFA-L-Valine-OSiMe3; (S)-2-((Trimethylsilyl)oxy)-3-methyl-1-(2,2,2-trifluoroacetamido)but-1-ene-1-one; TFA-L-Val-OTMS; Protected L-Valine derivative; Valine TFA silyl ester
EINECS	Contact for details

Quality Control

Our L-Valine, n-(Trifluoroacetyl)-, Trimethylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.