Description

(2S,3S,4R)-2-Carboxy-4-Isopropyl-3-Pyrrolidineacetic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a unique pyrrolidine backbone with multiple chiral centers. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly protease inhibitors. It is essential for research and development chemists and production teams in the pharmaceutical and biotechnology sectors who require high stereochemical purity for advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors and other biologically active compounds.
• Peptidomimetics Research: Serves as a constrained scaffold for designing and developing peptidomimetic molecules to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce complex stereochemistry.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs for various therapeutic targets.
• Bioconjugation & Labeling: The carboxylic acid groups provide handles for conjugation to other molecules, peptides, or solid supports.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S,3S,4R)-2-Carboxy-4-Isopropyl-3-Pyrrolidineacetic Acid
CAS No.	52497-36-6
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	(2S,3S,4R)-4-Isopropylpyrrolidine-2,3-dicarboxylic acid; (2S,3S,4R)-2,3-Pyrrolidinedicarboxylic acid, 4-(1-methylethyl)-; 4-Isopropyl-L-proline derivative; (2S,3S,4R)-4-(1-Methylethyl)-2,3-pyrrolidinedicarboxylic acid; 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropyl-, (2S,3S,4R)-; L-4-Isopropyl-2,3-pyrrolidinedicarboxylic acid (stereospecific); A chiral pyrrolidine-2,3-dicarboxylic acid derivative
EINECS	Contact for details

Quality Control

Our (2S,3S,4R)-2-Carboxy-4-Isopropyl-3-Pyrrolidineacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.