Description

(4Ar)-Decahydro-5α,6α-Dihydroxy-5,8Aβ-Dimethyl-3-Isopropylidenenaphthalen-2-One CAS NO 52483-04-2 is a complex, functionalized decalin derivative with significant potential as a key chiral intermediate in advanced organic synthesis. Its rigid, polycyclic structure bearing hydroxyl and ketone functionalities makes it a valuable building block for constructing complex molecular architectures. This compound is primarily sought by research institutions and pharmaceutical development teams for the synthesis of novel bioactive molecules, including potential drug candidates and natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for steroids, terpenoids, and other complex therapeutic agents.
• Organic Synthesis Building Block: Used in asymmetric synthesis and total synthesis projects to introduce the decalin core with specific stereochemistry and functional groups.
• Natural Product Analog Synthesis: Acts as a precursor for synthesizing analogs of natural products with modified biological activity for structure-activity relationship (SAR) studies.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodological development in catalysis and complex molecule construction.
• Fine Chemical Production: Utilized in the pilot-scale and commercial-scale manufacture of specialty chemicals requiring high-purity, complex intermediates.

Basic Information

Product Name	(4Ar)-Decahydro-5α,6α-Dihydroxy-5,8Aβ-Dimethyl-3-Isopropylidenenaphthalen-2-One
CAS No.	52483-04-2
Molecular Formula	C₁₅H₂₄O₃
Molecular Weight	252.35 g/mol
Synonyms	5,8a-Dimethyl-3-(propan-2-ylidene)decahydro-2H-naphthalene-2,5,6-triol; 3-Isopropylidene-5,8a-dimethyl-decahydro-naphthalene-2,5,6-triol; (4aR,5S,6S,8aS)-5,8a-Dimethyl-3-(propan-2-ylidene)decahydro-2H-naphthalene-2,5,6-triol; Decahydro-5,6-dihydroxy-5,8a-dimethyl-3-isopropylidene-2-naphthalenone; A key intermediate for forskolin analogs; Functionalized decalin ketone; Chiral decalin derivative.
EINECS	Contact for details

Quality Control

Our (4Ar)-Decahydro-5α,6α-Dihydroxy-5,8Aβ-Dimethyl-3-Isopropylidenenaphthalen-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.