Description

Polyethylene Glycol 4000 Dimesylate is a high-purity, bifunctional chemical intermediate derived from polyethylene glycol (PEG 4000). This compound is essential for creating stable, covalent linkages in advanced material synthesis and bioconjugation, offering precise control over molecular architecture. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries for developing drug delivery systems, cross-linked hydrogels, and functionalized surfaces.

Application

• Pharmaceutical Linker: A key reagent for the synthesis of antibody-drug conjugates (ADCs) and peptide-drug conjugates, enabling controlled drug release.
• Polymer Cross-linking Agent: Used to create stable, PEG-based hydrogels for biomedical applications such as tissue engineering scaffolds and controlled-release matrices.
• Surface Functionalization: Employed to modify nanoparticles, chromatography media, and diagnostic substrates with hydrophilic PEG chains to reduce non-specific binding.
• Bioconjugation Chemistry: Serves as a heterobifunctional spacer arm to attach proteins, peptides, or other biomolecules to solid supports or other macromolecules.
• Specialty Polymer Synthesis: Acts as a macro-initiator or chain extender in the production of block copolymers and dendrimers with tailored properties.
• Research & Development: A valuable tool in academic and industrial R&D for exploring novel drug delivery platforms and smart material designs.

Basic Information

Product Name	Polyethylene Glycol 4000 Dimesylate
CAS No.	52410-74-9
Molecular Formula	CnH2n+2O(n+1)S2 (n~90)
Molecular Weight	~4000 g/mol (Average)
Synonyms	PEG 4000 Dimesylate; Poly(oxy-1,2-ethanediyl), α,ω-bis(methanesulfonate); Polyethylene Glycol 4000 Dimethanesulfonate; Bis(methanesulfonyl) PEG 4000; α,ω-Bismesylate PEG 4000; PEG 4k Dimesylate; Methanesulfonic acid, 1,1'-[1,2-ethanediylbis(oxy-3,1-alkanediyl)] ester; Polyoxyethylene dimethanesulfonate (MW 4000)
EINECS	Contact for details

Quality Control

Our Polyethylene Glycol 4000 Dimesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and titration methods, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Polyethylene Glycol (PEG) Content	≤ 3.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Average Molecular Weight (GPC)	3700 - 4300

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.