Description

Tolyl Chloroformate CAS NO 52286-75-6 is a versatile and highly reactive chloroformate ester, primarily used as a key reagent for introducing the tolyloxycarbonyl protecting group in organic synthesis. Its reactivity makes it indispensable for the controlled synthesis of complex molecules, ensuring high yields and selectivity. This compound is critical for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable intermediates for peptide synthesis, polymer modification, and fine chemical production.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptide coupling and prodrug development.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where specific functional group protection is required.
• Polymer Chemistry: Serves as a modifying agent or chain terminator in the synthesis of specialty polymers and polycarbonates.
• Fine Chemical Production: Employed in the manufacture of dyes, pigments, and photographic chemicals.
• Bioconjugation & Labeling: Facilitates the attachment of reporter molecules or functional groups to biomolecules in research applications.
• Chemical Research & Development: A standard tool in organic synthesis labs for protecting amine and alcohol functionalities.

Basic Information

Product Name	Tolyl Chloroformate
CAS No.	52286-75-6
Molecular Formula	C8H7ClO2
Molecular Weight	170.59 g/mol
Synonyms	4-Tolyl Chloroformate; p-Tolyl Chloroformate; p-Methylphenyl Chloroformate; 4-Methylphenyl Chloroformate; Toluene-4-chloroformate; Chloroformic Acid p-Tolyl Ester; p-Tolyloxycarbonyl Chloride; (4-Methylphenyl) Carbonochloridate
EINECS	Contact for details

Quality Control

Our Tolyl Chloroformate is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identity confirmation (IR), and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.