Description

Glyburide (Potassium Salt) is a potent second-generation sulfonylurea derivative, specifically formulated as the potassium salt to enhance solubility and bioavailability. This compound is critical for its role as an oral hypoglycemic agent, effectively stimulating insulin secretion from pancreatic beta cells. It is an essential active pharmaceutical ingredient (API) for the formulation of anti-diabetic medications, primarily serving the global pharmaceutical manufacturing and advanced research sectors.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral medications for the management of type 2 diabetes mellitus.
• Formulation Development: Used in R&D for developing new solid dosage forms such as tablets and capsules with optimized release profiles.
• Generic Drug Manufacturing: Serves as a key starting material for the production of cost-effective generic anti-diabetic drugs.
• Biochemical Research: Employed in pharmacological studies to investigate insulin secretion mechanisms and β-cell function.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC and spectrometry.
• Combination Therapies: Investigated for use in fixed-dose combination drugs with other anti-diabetic agents like metformin.

Basic Information

Product Name	Glyburide (Potassium Salt)
CAS No.	52169-36-5
Molecular Formula	C23H28ClKN3O5S
Molecular Weight	527.10 g/mol
Synonyms	Glibenclamide Potassium Salt; Glybenzcyclamide Potassium; 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea Potassium Salt; N-[4-[β-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N′-cyclohexylurea Potassium Salt; 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide Potassium Salt; Daonil (related brand); Euglucon (related brand); Micronase (related brand)
EINECS	Contact for details

Quality Control

Our Glyburide (Potassium Salt) is manufactured under strict quality systems, with purity typically meeting or exceeding 98.5% (by HPLC). Production adheres to cGMP guidelines where applicable, ensuring consistency for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5%; Any single impurity ≤ 0.5%
Chromatographic Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.