Description

Ho-Peg5-Ch2Cootbu is a specialized bifunctional polyethylene glycol (PEG) derivative, serving as a versatile linker and spacer molecule in advanced chemical synthesis. Its core value lies in providing a hydrophilic, flexible PEG chain that enhances solubility and reduces immunogenicity in bioconjugation applications. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing antibody-drug conjugates (ADCs), peptide modifications, and polymer-based drug delivery systems.

Application

• Bioconjugation Linker: A critical component for coupling drugs, dyes, or other functional molecules to proteins, antibodies, or peptides.
• ADC (Antibody-Drug Conjugate) Development: Used to attach cytotoxic payloads to monoclonal antibodies, improving therapeutic index and solubility.
• PEGylation Reagent: Modifies therapeutic peptides and proteins to extend circulation half-life and improve stability.
• Polymer Chemistry Building Block: Serves as a monomer or cross-linker for synthesizing functionalized, biocompatible hydrogels and smart polymers.
• Diagnostic Probe Synthesis: Facilitates the attachment of imaging agents (e.g., fluorescent dyes, MRI contrast agents) to targeting molecules.
• Surface Functionalization: Used to create hydrophilic, non-fouling coatings on nanoparticles and medical devices.

Basic Information

Product Name	Ho-Peg5-Ch2Cootbu
CAS No.	52026-48-9
Molecular Formula	C24H46O9
Molecular Weight	478.62 g/mol
Synonyms	2,5,8,11,14-Pentaoxaheptadecane-17-oic acid, 16-hydroxy-, 1,1-dimethylethyl ester; tert-Butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate; HO-PEG5-CH2COOtBu; Hydroxy-PEG5-acid tert-butyl ester; 17-Hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oic acid tert-butyl ester; PEG5 spacer acid tert-butyl ester; α-Hydroxy-ω-carboxy(PEG)5 tert-butyl ester
EINECS	Contact for details

Quality Control

Our Ho-Peg5-Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.