Description

Nimesulide CAS NO 51803-78-2 is a non-steroidal anti-inflammatory drug (NSAID) belonging to the sulfonanilide class, known for its potent analgesic and antipyretic properties. It is a critical active pharmaceutical ingredient (API) valued for its selective inhibition of the COX-2 enzyme, which helps minimize certain gastrointestinal side effects associated with traditional NSAIDs. This compound is primarily required by pharmaceutical manufacturers and research institutions for the formulation of analgesic and anti-inflammatory medications, as well as for advanced pharmacological studies.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter analgesic and anti-inflammatory medications.
• Analgesic Formulations: Used in the development of drugs for the treatment of acute pain, including post-operative and dental pain.
• Anti-inflammatory Therapies: Incorporated into treatments for conditions involving inflammation, such as osteoarthritis and tendinitis.
• Antipyretic Medications: A key component in formulations designed to reduce fever.
• Veterinary Medicine: Applied in certain veterinary pharmaceutical products for pain and inflammation management in animals.
• Research & Development: Serves as a reference standard and a key intermediate in pharmacological research and the development of new therapeutic agents.

Basic Information

Product Name	Nimesulide
CAS No.	51803-78-2
Molecular Formula	C13H12N2O5S
Molecular Weight	308.31 g/mol
Synonyms	4-Nitro-2-phenoxymethanesulfonanilide; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide; R-805; Aulin; Mesulid; Nimeflex; Sca-263; Helsin; Heugan
EINECS	257-431-4

Quality Control

Our Nimesulide is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via techniques such as HPLC and IR spectroscopy. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which are available upon request to confirm compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Loss on Drying	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.