Description

(S)-Flurbiprofen CAS NO 51543-39-6 is the single enantiomer of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen, specifically targeting the cyclooxygenase (COX) enzyme. This high-purity chiral intermediate is critical for pharmaceutical R&D and manufacturing, enabling the development of more potent and selective therapeutics with potentially reduced side-effect profiles. It is primarily utilized by pharmaceutical companies and research institutions engaged in the synthesis of novel enantiomerically pure anti-inflammatory agents, chiral switches, and advanced drug delivery systems.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key chiral building block for the production of enantiomerically pure (S)-flurbiprofen as an active pharmaceutical ingredient.
• Chiral Drug Development: Essential reference standard and intermediate in R&D for novel NSAIDs and COX-2 selective inhibitors with improved efficacy.
• Biochemical Research: Used as a selective probe in pharmacological studies to investigate COX enzyme inhibition mechanisms and inflammatory pathways.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and chiral chromatography method development and validation.
• Preclinical Studies: Employed in animal model research for evaluating the pharmacokinetics and pharmacodynamics of the (S)-enantiomer.

Basic Information

Product Name	(S)-Flurbiprofen
CAS No.	51543-39-6
Molecular Formula	C15H13FO2
Molecular Weight	244.26 g/mol
Synonyms	(S)-2-Fluoro-α-methyl-4-biphenylacetic acid; (S)-2-(2-Fluorobiphenyl-4-yl)propanoic acid; Dexflurbiprofen; (S)-Flurbiprofen; S-(+)-Flurbiprofen; (2S)-2-(2-Fluorobiphenyl-4-yl)propanoic acid; (S)-3-Fluoro-4-phenylhydratropic acid; UNII-5V5IO2Q8F4
EINECS	257-244-3

Quality Control

Our (S)-Flurbiprofen is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, enantiomeric excess (ee) determination, and impurity profiling to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to comply with relevant pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.