Description

α-(2-Carboxyethyl)-ω-(2-Carboxyethoxy)Poly(Oxy-1,2-Ethanediyl) is a high-purity, functionalized polyethylene glycol (PEG) derivative, also known as a dicarboxylated PEG. This compound matters for its unique bifunctional carboxylic acid end groups, which provide versatile reactivity for conjugation, cross-linking, and surface modification in advanced material synthesis. It is essential for R&D and production teams in the pharmaceutical, biomedical, and specialty polymer industries who require precise, water-soluble linkers and modifiers.

Application

• Pharmaceutical Conjugation: Used as a linker for attaching drugs, peptides, or targeting ligands in prodrug and bioconjugate development.
• Biomaterial Modification: Functionalizes surfaces of nanoparticles, hydrogels, and medical devices to enhance biocompatibility and introduce reactive sites.
• Polymer Synthesis: Serves as a difunctional monomer or macroinitiator for creating degradable, cross-linked, or amphiphilic copolymers.
• Diagnostic Reagents: Employed in the preparation of stabilized enzyme conjugates and fluorescent probes for assay kits.
• Cosmetic Formulations: Acts as a high-performance emulsifier and stabilizer in advanced skincare products.
• Chromatography & Separation: Utilized as a stationary phase modifier or as a component in aqueous two-phase systems for protein purification.

Basic Information

Product Name	α-(2-Carboxyethyl)-ω-(2-Carboxyethoxy)Poly(Oxy-1,2-Ethanediyl)
CAS No.	51178-68-8
Molecular Formula	CnH2n+2On+4 (Variable, based on PEG chain length 'n')
Molecular Weight	Variable (Contact for details on specific grades)
Synonyms	Dicarboxy PEG; PEG-diacid; Poly(ethylene glycol) bis(carboxymethyl) ether; α,ω-Bis(carboxy)-PEG; HOOC-PEG-COOH; Polyoxyethylene bis(glycolic acid); Carboxylated polyethylene glycol; PEG diacid derivative
EINECS	Contact for details

Quality Control

Our α-(2-Carboxyethyl)-ω-(2-Carboxyethoxy)Poly(Oxy-1,2-Ethanediyl) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including NMR for structural confirmation, HPLC/GPC for purity and molecular weight distribution, and acid value titration to quantify functional end groups. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term stability, consider storing under an inert atmosphere or in a desiccator to prevent moisture uptake and potential hydrolysis of the ester linkages.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Acid Value)	> 95% (or as per grade)
Purity (HPLC)	> 98.0%
Molecular Weight (GPC)	As per ordered grade (e.g., 600, 1000, 2000 Da)
Polydispersity Index (PDI)	< 1.10
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.