Description

(S)-(+)-Ibuprofen CAS NO 51146-56-6 is the pharmacologically active enantiomer of the widely used non-steroidal anti-inflammatory drug (NSAID) ibuprofen. This high-purity chiral intermediate is critical for developing enantiomerically pure pharmaceuticals with enhanced efficacy and reduced side-effect profiles. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and advanced fine chemical producers focused on innovative analgesic and anti-inflammatory formulations.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key chiral building block for the production of single-enantiomer ibuprofen and related proprietary NSAIDs.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacokinetics and pharmacodynamics of the (S)-enantiomer.
• Chiral Catalyst & Ligand Development: Acts as a precursor or scaffold for synthesizing novel chiral catalysts and ligands used in asymmetric synthesis.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, GC, and chiral separation methods for quality control and regulatory testing.
• Advanced Formulation Development: Integral to creating next-generation drug delivery systems, such as transdermal patches or targeted release formulations, requiring the pure enantiomer.
• Biochemical Studies: Utilized in enzymatic and receptor-binding assays to study the specific interaction and inhibition mechanism of cyclooxygenase (COX) enzymes.

Basic Information

Product Name	(S)-(+)-Ibuprofen
CAS No.	51146-56-6
Molecular Formula	C13H18O2
Molecular Weight	206.28 g/mol
Synonyms	(S)-(+)-2-(4-Isobutylphenyl)propionic acid; Dexibuprofen; (S)-Ibuprofen; (+)-Ibuprofen; (2S)-2-[4-(2-Methylpropyl)phenyl]propanoic acid; S(+)-Ibuprofen; (S)-p-Isobutylhydratropic Acid; Dexibuprofenum
EINECS	Contact for details

Quality Control

Our (S)-(+)-Ibuprofen is manufactured under strict quality management systems. We provide material that typically meets or exceeds pharmaceutical-grade standards, with rigorous controls for enantiomeric excess (ee), chemical purity, and impurity profiles. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and related substances are available for every batch upon request, ensuring full traceability and compliance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is stable under these conditions but should be kept away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	52 - 55 °C
Specific Rotation ([α]D20)	+54° to +58° (c=1, CHCl3)
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.