Description

(1'S,2'S)-Nicotine 1'-Oxide CAS NO 51095-86-4 is a specific stereoisomer of nicotine N-oxide, a key metabolite and derivative of nicotine. This compound is of significant interest in pharmaceutical and biochemical research due to its role in nicotine metabolism and its potential as a reference standard. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical developers engaged in nicotine-related studies, toxicology, and the development of smoking cessation aids or diagnostic assays.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the calibration of analytical instruments and validation of testing methods in pharmacokinetic studies.
• Metabolite Research: Critical for investigating the metabolic pathways, bioavailability, and excretion profiles of nicotine in both clinical and preclinical settings.
• Toxicological Studies: Employed in studies assessing the biological impact and safety profile of nicotine and its derivatives.
• Analytical Chemistry: Serves as a critical standard in HPLC, LC-MS, and GC-MS analyses for the accurate quantification of nicotine metabolites in various biological matrices.
• Biochemical Reagent: Used in enzymatic and receptor-binding assays to study the interaction and effects of nicotine derivatives.
• Product Development: May be used in R&D for novel nicotine replacement therapies (NRTs) or other therapeutic agents targeting nicotine addiction.

Basic Information

Product Name	(1'S,2'S)-Nicotine 1'-Oxide
CAS No.	51095-86-4
Molecular Formula	C10H14N2O
Molecular Weight	178.23 g/mol
Synonyms	(1'S,2'S)-Nicotine N-Oxide; (-)-Nicotine 1'-Oxide; (S)-Nicotine 1'-Oxide; Nicotine 1'-N-Oxide; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine 1-oxide; Nicotine N-Oxide (stereospecific); 1-Methyl-2-(3-pyridyl)pyrrolidine 1-oxide
EINECS	Contact for details

Quality Control

Our (1'S,2'S)-Nicotine 1'-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet stringent specifications for research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Due to its sensitivity to oxidation, prolonged exposure to air should be minimized.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by chiral HPLC)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.