Description

1-[3-[(Trifluoromethyl)Thio]Phenyl]Piperazine is a high-purity, functionalized piperazine derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethylthio-phenyl moiety imparts desirable physicochemical properties. It is primarily utilized by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate and scale new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethylthio group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and functional materials with tailored electronic or surface properties.
• Chemical Biology Probes: Useful for creating molecular probes to study biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1-[3-[(Trifluoromethyl)Thio]Phenyl]Piperazine
CAS No.	50786-80-6
Molecular Formula	C11H13F3N2S
Molecular Weight	262.29 g/mol
Synonyms	1-[3-[(Trifluoromethyl)thio]phenyl]piperazine; 3-[(Trifluoromethyl)thio]phenylpiperazine; 1-(3-((Trifluoromethyl)thio)phenyl)piperazine; 3-(Trifluoromethylthio)phenylpiperazine; 1-(3-(Trifluoromethylsulfanyl)phenyl)piperazine; Piperazine, 1-[3-[(trifluoromethyl)thio]phenyl]-; 50786-80-6; 3-(Piperazin-1-yl)phenyl trifluoromethyl sulfide
EINECS	Contact for details

Quality Control

Our 1-[3-[(Trifluoromethyl)Thio]Phenyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.