Description

Piperazine, 1-(4,5-Dihydro-4-Methyl-2-Oxazolyl)-, (R)- (9Ci) is a chiral, non-racemic piperazine derivative featuring an oxazoline moiety, serving as a sophisticated building block in asymmetric synthesis. This compound matters for its role as a key chiral intermediate and ligand precursor, enabling the production of high-value, optically active pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereochemistry into complex molecules. The product is supplied with a CAS Number of 50693-80-6.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Catalyst Ligand: Serves as a precursor for chiral oxazoline-based ligands used in transition metal catalysis (e.g., palladium, copper) for enantioselective C-C and C-N bond-forming reactions.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for research and commercial scale-up.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	Piperazine, 1-(4,5-Dihydro-4-Methyl-2-Oxazolyl)-, (R)- (9Ci)
CAS No.	50693-80-6
Molecular Formula	C8H15N3O
Molecular Weight	169.22 g/mol
Synonyms	(R)-1-(4-Methyl-4,5-dihydrooxazol-2-yl)piperazine; (R)-2-(1-Piperazinyl)-4-methyl-4,5-dihydrooxazole; (R)-2-Piperazin-1-yl-4-methyl-4,5-dihydro-1,3-oxazole; (R)-4-Methyl-2-(piperazin-1-yl)-4,5-dihydrooxazole; (R)-Methyloxazolylpiperazine; Chiral Oxazolylpiperazine Derivative
EINECS	Contact for details

Quality Control

Our chiral intermediates are produced under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including Chiral HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.