Description

n-(n-Butoxycarbonyl)Piperazine is a versatile and high-purity chemical intermediate, primarily used as a key building block in organic synthesis. Its value lies in the Boc (tert-butoxycarbonyl) protecting group, which is crucial for the controlled synthesis of complex molecules, particularly in peptide chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, antipsychotics, and other nitrogen-containing heterocycles.
• Peptide Synthesis: Serves as a protected piperazine derivative, enabling the controlled introduction of the piperazine moiety into peptide chains during solid-phase or solution-phase synthesis.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate piperazine-based structures.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal catalysis and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or chain extender in the synthesis of specialty polyamides, polyurethanes, and other performance polymers.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	n-(n-Butoxycarbonyl)Piperazine
CAS No.	50606-32-1
Molecular Formula	C9H18N2O2
Molecular Weight	186.25 g/mol
Synonyms	1-Boc-piperazine; N-Boc-piperazine; 1-(tert-Butoxycarbonyl)piperazine; tert-Butyl 1-piperazinecarboxylate; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-; 4-(tert-Butoxycarbonyl)piperazine; Boc-Piperazine; UNII-0N2I4B22R8
EINECS	Contact for details

Quality Control

Our n-(n-Butoxycarbonyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can supply material compliant with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	86 - 90 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.